Transcranial magnetic stimulation studies in the Miller Fisher syndrome: evidence of corticospinal tract abnormality.

OBJECTIVES To evaluate serial central motor conduction time in the Miller Fisher syndrome. METHOD Three patients with classic Miller Fisher syndrome were evaluated clinically. They had serial central motor conduction times measured with transcranial magnetic stimulation and nerve conduction studies. Motor evoked potentials were recorded from the first dorsal interossei and abductor hallucis muscles. RESULTS All three patients showed reduction in central motor conduction times in tandem with gradual clinical improvement at each review. CONCLUSIONS There is electrophysiological evidence of a central reversible corticospinal tract conduction abnormality in the Miller Fisher syndrome.